Users' questions

Does CIN 2 Go Away?

Does CIN 2 Go Away?

CIN 2 lesions often clear up on their own, but can also progress to CIN 3 lesions. CIN 3 is the most severe. It’s a very slow-growing disease, though: fewer than half of CIN 3 lesions will have become cancer within 30 years.

How long does it take for CIN 2 to become cancer?

The median time from CIN2/3 to cancer was estimated to be 23.5 years (95% confidence interval: 20.8, 26.6), and 1.6% of the lesions progressed to cancer within 10 years.

Is CIN 2 precancerous?

Moderately abnormal cells are found on the surface of the cervix. CIN 2 is usually caused by certain types of human papillomavirus (HPV) and is found when a cervical biopsy is done. CIN 2 is not cancer, but may become cancer and spread to nearby normal tissue if not treated.

Can a normal cervix be affected by cervical cancer?

Abnormal cell changes in the cervix are common and often improve naturally. But sometimes they can develop into cancer of the cervix ( cervical cancer ). Abnormal changes cause no symptoms. So you will not know if you are affected unless you have cervical screening. Screening finds any abnormal cell changes.

Which is the best treatment for CIN2 and CIN3?

A comparison of surgical modalities based on randomised trials reported relative equivalence in effectiveness and safety. Hysterectomy as a primary treatment of CIN2 or CIN3 may also be an option for women who are not considering a future pregnancy and have an associated benign gynaecological disease.

How is the rate of cervical cancer decreasing?

These numbers are staggering, especially when cervical cancer is one of the most preventable cancers in women. Fortunately, the death rate from cervical cancer has decreased by more than 50 percent over the last 40 years, due to increased use of the Pap test and HPV (Human papillomavirus) vaccination.

When to use p16 positivity in CIN2 diagnoses?

The reproducibility of CIN2 diagnoses has historically been poor and low inter-observer agreement has been reported. This is the basis for the LAST recommendation to use p16 positivity in lesions which would be called CIN2 on H&E histopathology, in order to confirm the presence of active oncogenic HPV DNA in these lesions.

Can a Cin cause cancer of the cervix?

CIN is not cancer. But if the abnormal area is not treated, over time it may develop into cancer of the cervix (cervical cancer). CIN does not cause any symptoms. You are not likely to find out you have it unless you have cervical screening.

What to do about CIN 3 cervical cancer?

CIN 3 has a higher risk of developing into cervical cancer. You are usually offered treatment to prevent this happening. Sometimes the doctor or nurse can see that the cells are very abnormal during the colposcopy. They may offer you treatment to remove these cells straight away.

When does CIN 1 and 2 turn into cancer?

It’s during that wait-and-see period that they fear that CIN 1 will turn into cancer, even though the follow-up Pap may be scheduled for only six months out. “Most CIN 1 and 2 will resolve spontaneously (75%),” says Julian Schink, MD, Chief of Gynecologic Oncology, Cancer Treatment Centers of America;

How is cervical intraepithelial neoplasia ( CIN ) diagnosed?

How is cervical intraepithelial neoplasia (CIN) diagnosed? Since CIN usually does not cause any symptoms, a Pap smear is needed to find abnormal cells. If the Pap test is unclear or abnormalities are found, the next step might be a colposcopy to examine the cervix and surrounding structures under a microscope.